ABSTRACT
Background: Medication disposal is one of the topics overlooked by the population in the United Arab Emirates. The present study aims at assessing the knowledge, attitude and practice of public to appropriate disposal of medications in Sharjah, UAE.Methods: A cross-sectional study on randomly selected subjects was conducted using a pre-piloted questionnaire written in Arabic and English and distributed to 250 subjects. The survey was designed with 22 questions to assess knowledge, attitude and practice on safe disposal of expired medication.Results: More than half (120, 54.8 %) of the participants were females of age 17-25 (100, 45.7%) and with a university or a higher degree (124, 56.6%). A total of 131 (59.8%) of the participants reported that they do not take any precautions when disposing hazardous products and they just throw them in the general waste. Regardless of their educational level, 90 (41.1%) of the respondents believed that throwing medications in the general waste is the safest way of disposal. The majority of participants (202, 92.3%) reported that they never received counselling from pharmacists on safe disposal of expired and unused medications.Conclusions: International guidelines on safe medication disposal need to be adopted by health authorities. Providing secure collection boxes in various residential areas and increasing public awareness of medication抯 safe disposal are important steps that could be implemented in the UAE. Pharmacists should also play a major role in guiding and instructing patients on this topic.
ABSTRACT
Abstract Securigera securidaca (L.) Degen & Döefl., Fabaceae, has been widely used in the Iranian, Indian and Egyptian folk medicine as antidiabetic and anti-hyperlipidemic remedy. Phenolic profiling of the ethanolic extract (90%) of the flowers of S. securidaca was performed via HPLC-DAD-MS/MS analysis in the positive and negative ion modes. The total polyphenols and flavonoids in the flowers were determined colorimetrically, and the quantification of their components was carried out using HPLC-UV. Total phenolics and flavonoids estimated as gallic acid and rutin equivalents were 82.39 ± 2.79 mg/g and 48.82 ± 1.95 mg/g of the dried powdered flowers, respectively. HPLC-DAD-MS/MS analysis of the extract allowed the identification of 39 flavonoids and eight phenolic acids. Quantitative analysis of some flavonoids and phenolics (mg/100 g powdered flowers) revealed the presence of isoquercetrin (3340 ± 2.1), hesperidin (32.09 ± 2.28), naringin (197.3 ± 30.16), luteolin (10.247 ± 0.594), chlorogenic acid (84.22 ± 2.08), catechin (3.94 ± 0.57) and protocatechuic acid (34.4 ± 0.15), in the extract. Moreover, the acute toxicity, hypoglycemic and hypolipidemic effects of the extract were investigated using alloxan induced diabetes in rats in a dose of 100, 200, and 400 mg/kg bwt. The ethanolic extract was safe up to a dose of 2000 mg/kg. All tested doses of the flower extract showed marked decrease in blood glucose level by 31.78%, 66.41% and 63.8% at 100, 200 and 400 mg/kg bwt, respectively, at p < 0.05. Regarding the anti-hyperlipidemic effect, a dose of 400 mg/kg of the flower extract showed the highest reduction in serum triacylglycerides and total cholesterol levels (68.46% and 51.50%, respectively at p < 0.05). The current study proved the folk use of the flowers of S. securidaca as anti-diabetic and anti-hyperlipidemic agent which could be attributed to its high phenolic content.